FRIGE scientists develop India's first national biobank for Lysosomal Storage Disorders

**Scientists develop and deploy India's first national biobank for rare disease- Lysosomal Storage Disorders- comprising of over 500 patients.**

Breakthrough in understanding the genetic cause of severe male infertility in India

**Sequencing based technology is developing a new paradigm in understanding the cause and providing tailored reproductive options to men with infertility, data from a large cohort shows.**

Advertisement for two Junior Research Fellows

We are a world class research-intensive institute. We deliver clinical diagnostics, genetic counselling, teaching and R&D of the highest quality. Attracting and retaining high-calibre people is fundamental to our continued success.

Advertisement for Research Associate

* We are a world class diagnostics and research-intensive institute. We deliver clinical diagnostics, genetic counselling, teaching and R&D of the highest quality. Attracting and retaining high-caliber people is fundamental to our continued success.

FRIGE - Internship and Training Program (Winter Edition 2025)

Genetics is currently going through a rapid expansion in its suite of techniques and technologies. Understanding these technologies and utilising them in clinical research and diagnostic settings is key for their robust implementation in clinics.

FRIGE scientists analyse utility of prenatal diagnosis for preventing rare genetic disorders in India

**Systematic analysis of data of over 1700 prenatal samples from tertiary centre during 14 year period shows ~25% babies affected with a genetic disease.**

FRIGE scientists decipher role of structural variants in autism

**India's first systematic and cutting-edge genetic study in 23 children with autism spectrum disorder explored the role of long-read whole genome sequencing and structural variants in the cause of autism.**

FRIGE - Internship, Training and Dissertation Program (Summer Edition 2025)

Genetics is currently going through a rapid expansion in its suite of techniques and technologies. Understanding these technologies and utilising them in clinical research and diagnostic settings is key for their robust implementation in clinics.

Advertisement for a Junior Research Fellow- Molecular Genetics

We are a world class diagnostics and research-intensive institute. We deliver clinical diagnostics, genetic counselling, teaching and R&D of the highest quality. Attracting and retaining high-calibre people is fundamental to our continued success.

FRIGE scientists discover India's first founder variant in MLH1 gene associated with Lynch syndrome

**Founder variant that is observed in approximately 6.4% of all Lynch syndrome patients, the most common hereditary cancer disease, has been discovered.**

FRIGE scientists analyse burden of complex chromosomal rearrangements in India

**Systematic analysis of data of over 4200 couples with clinical history of repeated foetal loss from tertiary centre during 30 year period shows role of complex chromosomal rearrangements.**

FRIGE part of the International Human Ring Chromosome consoritum

A large international collaboration consisting of teams from USA, UK, Europe and India are working together to understand the incidence, aetiology, detection mechanisms and guideline preparation.

FRIGE scientists analyse burden of rare genetic disorders in India

**Systematic analysis of data of over 3000 patients from tertiary centre during 22 year period shows 3000 patients with rare genetic diseases across 14 major disease groups.**

FRIGE-Sanofi DISHA Program: Free of cost diagnosis for common lysosomal storage disorders

FRIGE and Sanofi have partnered to develop DISHA program- a comprehensive program for diagnosis of common lysosomal storage disorders in India.

30th Anniversary of Genetics Pioneer Institution

An institution that started from a small room with a dining table has metamorphized into a state-of-art diagnostics and translation research powerhouse in the arena of genetics and genomics in India.

Advertisement for a Senior Cytogeneticist

We are a world class diagnostics and research-intensive institute. We deliver clinical diagnostics, genetic counselling, teaching and R&D of the highest quality. Attracting and retaining high-calibre people is fundamental to our continued success.

FRIGE - Internship, Training and Dissertation Program (Winter Edition)

Genetics is currently going through a rapid expansion in its suite of techniques and technologies. Understanding these technologies and utilising them in clinical research and diagnostic settings is key for their robust implementation in clinics.

Celebrating Autism awareness month and World Parkinson Day

With neurological disorders on the rise, understanding their cause, diagnostic methods, management, treatment and prevention is ever more crucial than before.

FRIGE scientists initiate study on hereditary cancer

**India's first systematic epidemiological study on the genetic contribution behind common cancers begins.**

Improving understanding of the role of NEUROG1 gene in autism

A large study in Indian children with autism identified NEUROG1 to play a role in causing autism spectrum disorder together with cranial dysinnervation syndrome.

48th Annual Meeting and International Conference of the Indian Society of Human Genetics

India's biggest human genetics and genomics meet of 2024 is organised by the Foundation for Research in Genetics and Endocrinology along with Gujarat Biotechnology Research Centre.

FRIGE scientists decipher genetic architecture of autism in India

**India's first systematic genetic study in 101 children with autism spectrum disorder has shown a significant contribution of *de novo* mutation towards aetiology of ASD.**

FRIGE and Dr Jivraj Mehta Hospital join hands to create state-of-the-art Genetics OPD in public hospital

FRIGE and Dr. Jivraj Mehta Hospital begin a new chapter in personalised, precision and preventative healthcare by launching the first genetics OPD at the hospital.

Nobel Prize in Physiology or Medicine 2022- Ancient Human DNA and Human Evolution

Svante Paabo made pathbreaking discoveries on human evolution using ancient DNA of Neanderthals and Denisovans- and his work spawned the field of palaeogenomics.

Daily resistant starch prevents cancers in Lynch syndrome patients

**A randomised controlled trial in people with Lynch syndrome has shown a significant cancer prevention effect from resistant starch, found in a range of daily food items such as slightly green bananas and oats.**

Legacy and celebrations of 200 years of Mendel and Mendelian Genetics

An Augustinian friar, teacher, mathematician and a citizen scientist at heart- Gregor Mendel's work described the principles of inheritance that still stand today.

Advertisement for academic and diagnostic positions

We are a world class diagnostics and research-intensive institute. We deliver clinical diagnostics, genetic counselling, teaching and R&D of the highest quality. Attracting and retaining high-calibre people is fundamental to our continued success.

FRIGE-ISPAT Analysis and interpretation of NGS data in clinic workshop

Breakthrough in understanding cause of male infertility

A large multinational collaboration consisting of teams from the UK, Europe, USA, Australia and India have identified a new genetic mechanism that can cause severe forms of male infertility.

FRIGE 4 Months Dissertation Course

Genetics is currently going through a rapid expansion in its suite of techniques and technologies. Understanding these technologies and using them in research and diagnostic settings is key for their robust implementation in clinics.

FRIGE and CHARUSAT University inks MOU for collaborative research & educational exchanges

FRIGE and Charotar University of Science and Technology (CHARUSAT) signs memorandum of undertaking to carry out collaborative research in human genetics and educational exchange.

FRIGE and GTU inks MOU for collaborative research

FRIGE and Gujarat Technological university signs memorandum of undertaking to carry out collaborative research in human genetics, computational biology and biotechnology.

Milestone of 1 billion COVID19 vaccinations in India

India has created a milestone in vaccination by administrating over a billion Covid jabs since it started its vaccination drive in January of this year.

Advertisement for a Laboratory Technician

We are a world class diagnostics and research-intensive institute. We deliver clinical diagnostics, genetic counselling, teaching and R&D of the highest quality. Attracting and retaining high-calibre people is fundamental to our continued success.

Mutation, variant and vaccination strategies for COVID19

Mutational processes that lead to new COVID19 virus variants can affect vaccination strategies and public health measures. In this interview, Dr. Harsh Sheth explains what mutation is and how COVID19 variants develop.

20th Anniversary of Human Genome Project and Rare Disease Day

The Human Genome Project gave new paradigm in which medicine became personalised, predictive and preventitive.

Highest quality biochemical testing certification for 2021- ERNDIM

ERNDIM certification ensures highest quality of standardised procesudre for diagnosis, treatment and monitoring of inherited metabolic diseases are followed.

Highest quality molecular genetics testing certification- EMQN

Europen Molecular Quality Network's (EMQN) external quality assessment (EQA) certification ensures highest quality of the entire analytical process of a molecular diagnostics lab including the ability to interpret complex data and produce an accurate diagnostic test report.

New coronavirus strain and its impact on vaccine strategy

With the new COVID19 virus strain (B1.1.7.) throwing the entire world into a frenzied state, it is important to understand its impact on healthcare and vaccine strategies.

Vaccine development stage and clinical trials against coronavirus - COVID19

With more than 180 vaccines are currently being developed against COVID19 virus, it important than ever to understand the approaches for developing vaccines and how they will be distributed across the world.

Predicting acute inflammation response in COVID-19 patients

Predicting the course of COVID-19 is essential for best treatment outcome for the patients.

Chemistry Nobel Prize 2020- CRISPR DNA Editing Technology

CRISPR-Cas9 is one of only a handful of technological marvels that have made a paradigm shifting and lasting impact on healthcare.

Advertisement for a Research Fellow

We are a world class research-intensive institute. We deliver clinical diagnostics, genetic counselling, teaching and R&D of the highest quality. Attracting and retaining high-calibre people is fundamental to our continued success.

Vaccine development against coronavirus - COVID19

More than 200 vaccines are currently being developed against COVID19 virus, across the globe. What is the structure of coronavirus and what strategies are used for developing vaccines is discussed in a live interview with Doordarshan Girnar.

Daily aspirin prevents bowel cancer in Lynch syndrome patients

**Taking aspirin regularly can prevent bowel cancer in high-risk patients even after ‘20 years’, data from randomised controlled trial shows.**

Highest quality biochemical testing certification- ERNDIM

ERNDIM certification ensures highest quality of standardised procesudre for diagnosis, treatment and monitoring of inherited metabolic diseases are followed.

COVID-19: Impact on India (Student Blog)

A detailed analysis on the impact of covid19 outbreak on India penned by the students of FRIGE.

Genetics of coronavirus - COVID19

Several research groups, hospitals, nations and the World Health Organisation (WHO) have been playing active role to sequence the RNA of the COVID19 virus. Its purpose and utility is discussed in a live interview with the Gujarat Samachar TV.

Mutation spectrum in autism spectrum disorders in India

Diagnosing autism spectrum disorders (ASDs) is often challenging as mutation in several genes can lead to the disease. Systematic application of latest genomic technologies could improve diagnosis and reduce cost.

Low cost diagnosis of common lysosomal storage disorders

Diagnosis of lysosomal storage disorders (LSD) is often challenging due to overlapping clinical symptoms and costly chemicals. We are developing a sequencing based assay that can diagnose over 20 LSDs simultaneously.

The Great and the Good

Over our 25 years history, we have been fortunate to meet and receive praise from noted dignitories, scientists and the general public. Their words enthuse us to strive towards excellence in delivering diagnostics and research.

FRIGE - Internship, Training and Dissertation Program (Summer Edition)

Genetics is currently going through a rapid expansion in its suite of techniques and technologies. Understanding these technologies and utilising them in clinical research and diagnostic settings is key for their robust implementation in clinics.

A novel suite of biochemical diagnostic tests for Lysosomal Storage Disorders

Lysosomal Storage Disorders (LSDs) are a group of 70 diseases that are characterised by an impaired lysosome enzyme and occurs in 1 in 5000 births. Diagnosing these diseases is extremely challenging as it requires accurate clinical data collection and subsequent use of specific lysosomal enzyme substrates.

Next generation microsatellite instability test

Colorectal cancer, also known as bowel cancer, is the sixth most common cancer in India. National health agencies of USA, UK, France and India. recommend all bowel cancers to be tested for a specific type of “DNA spelling mistakes” called microsatellite instability or MSI for short.